Search results for "No carrier added"

showing 3 items of 3 documents

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

2011

4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield.

Fluorine Radioisotopespositron emission tomographyTwo stepNo carrier addedPharmaceutical ScienceThiophenesMedicinal chemistryAnalytical Chemistrylcsh:QD241-441chemistry.chemical_compoundOnium CompoundsPhenolsNucleophilelcsh:Organic chemistryBromideDrug DiscoveryMoietyOrganic chemistryPhysical and Theoretical Chemistrydiaryl iodonium saltsCommunicationOrganic ChemistrySynthonRadiosynthesischemistryChemistry (miscellaneous)fluorine-18Molecular MedicineradiosynthesisRadiopharmaceuticalsFluoride4-[18F]fluorophenolMolecules
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Direct flow separation strategy, to isolate no-carrier-added 90Nb from irradiated Mo or Zr targets

2016

Abstract 90Nb has an intermediate half-life of 14.6 h, a high positron branching of 53% and optimal β + emission energy of only E mean 0.35 MeV per decay. These favorable characteristics suggest it may be a potential candidate for application in immuno-PET. Our recent aim was to conduct studies on distribution coefficients for ZrIV and NbV in mixtures of HCl/H2O2 and HCl/oxalic acid for anion exchange resin (AG 1 × 8) and UTEVA resin to develop a “direct flow” separation strategy for 90Nb. The direct flow concept refers to a separation accomplished using a single eluent on multiple columns, effectively streamlining the separation process and increasing the time efficiency. Finally, we also …

03 medical and health sciences0302 clinical medicineChemistry030220 oncology & carcinogenesisNo carrier addedAnalytical chemistryIrradiationPhysical and Theoretical ChemistryDirect flow030218 nuclear medicine & medical imagingRadiochimica Acta
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A no-carrier-added 72Se/72As isotope generator

2001

Siinznrary A no-carrier-added 72Se/72As generator has been developed for the isolation of 72As, relevant for eventual application in the syntheses of 72As-labelled radiophamaceuticals. Avoiding the addition of Se carrier and using a thennochromatographic destillation process, no-carrier-added 72As is nearly quantitatively released within 10 min. 72Se remains almost quantitatively (> 99.7%) in solution when a temperature of the separation process of 100°C is applied. Introdiiction Arsenic-72 is a positron emitting isotope with properties which are promising for eventual application in 72As-labelled radiopharmaceuticals. It has n positron emission rate of 88% and positron energies of EP+,,,,~…

PhotonIsotopeChemistryGenerator (category theory)Organic ChemistryRadiochemistryNo carrier addedCyclotronBiochemistryAnalytical ChemistrySeparation processlaw.inventionPositronlawDrug DiscoveryRadiology Nuclear Medicine and imagingPositron emissionSpectroscopyJournal of Labelled Compounds and Radiopharmaceuticals
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